Normal pregnancy is accompanied by changes in the coagulation and fibrinolytic systems. These include increases in a number of clotting factors (I, II, VII, VIII, IX and XII), a decrease in protein S levels and inhibition of fibrinolysis. Although most coagulation factors increase during pregnancy, factor XIII (fibrin stabilizing factor) and now factor XI have been shown to decrease.
Normal pregnancy is accompanied by changes in the coagulation and fibrinolytic systems. These include increases in a number of clotting factors (I, II, VII, VIII, IX and XII), a decrease in protein S levels and inhibition of fibrinolysis. Although most coagulation factors increase during pregnancy, factor XIII (fibrin stabilizing factor) and now factor XI have been shown to decrease.